Page 41 - ESGO - Vulvar cancer - Complete report_fxd2

Original studies presenting data in patients treated with neoadjuvant chemoradiation (continued)

Authorreference Year N Chemotherapy regimen Radiotherapy re
Carson et al.a,255 1990 LAVC: N = 6
5-FU 750 mg/m² infusion d1-5 + MMC 7.5 mg/m² 45-50 Gy in 1.75
Levin et al.247 Recurr.: N = 2 IVd4 + CisP 0mg/m² IV d1, given weekly during
radiotherapy.
1986 LAVC: N = 6
5-FU 1000 mg/m² infusion d1-4 + MMC 10 mg/² 20-40 Gy in 2 Gy
IV d1. 1-2 cycles

Koh et al.233 1993 LAVC: N = 4 5-FU 750-1,000 mg/m²/d for 3-4 d 40-44.8 Gy

a Radiotherapy given to the vulva, groin and pelvis unless otherwise stated, 5-FU: 5-fluorouracil, CisP: cisplatin, CR: com
available, NED: no evidence of disease and no recurrence, pCR: pathologic complete response, PR: partial response, prog.: p

 VULVAR CANCE
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