Page 12 - Ovarian Cancer Surgery - Quality Indicators

Table 1. Original studies presenting survival multivariate analysis in patients with advanced ovarian
cancer treated with primary cytoreductive surgery

Authorreference Year N Optimal Residual Multivariate analysis*
Total criteria disease HR/OR 95% CI
p-value

Overall survival

Akeson et al.159 2009 3911 no gross ≤ 20 mm 1.9 1.2-3.3 < 0.05
Akeson et al.159 2009 3911 no gross > 20 mm 2.6 1.6-4.2 < 0.05
Fotopoulou et al.160 2010 1012 no gross > 1 mm 4.99 2.3-10.85 < 0.001
Landrum et al.161 2013 428 no gross ≤ 5 mm 1.87 1.34-2.62 < 0.001
Landrum et al.161 2013 428 no gross > 5 mm 2.03 1.31-3.15 0.001
Polterauer et al.162 2012 2263 no gross > 1 mm 1.4 1.0-2.1 0.04
Wimberger et al.163 2010 573 no gross ≤ 10 mm 1.87 1.21-2.89 0.005
Wimberger et al.163 2010 573 no gross > 10 mm 2.13 1.40-3.23 < 0.0001
Chang et al.164 2012 189 no gross ≤ 10 mm 2.25 1.25-4.03 0.01
du Bois et al.165 2009 3,1265 no gross ≤ 10 mm 2.12 1.85-2.43 < 0.0001
Cai et al.166 2007 95 <10 mm ≥ 10 mm 4.084 1.521-10.968 0.005
Fu et al.167 2014 251 <10 mm NA 1.586 0.863-1.575 0.137
Gerestein et al.168 2009 118 <10 mm ≥ 10 mm 0.50 0.27-0.93 0.028
Kaern et al.169 2005 51 <10 mm ≥ 10 mm 19.5 1.5-249.9 < 0.05
Marth et al.183 2009 1,948 <10 mm ≥ 10 mm 1.5 1.25-1.81 < 0.001
Abaid et al.170 2011 75 ≤ 10 mm > 10 mm 1.18 0.36-3.87 > 0.05
Chang et al.171 2012 203 ≤ 10 mm > 10 mm 3.24 1.90-5.53 < 0.01
Gadducci et al.172 2005 315 ≤ 10 mm > 10 mm 1.985 1.307-3.015 0.0013
Pongsanon et al.173 2011 122 ≤ 10 mm > 10 mm 4.05 1.34-12.18 0.013
Eisenhauer et al.174 2006 140 ≤ 10 mm > 10 mm 2.99 1.64-5.45 < 0.001
Ayhan et al.179 2006 646 ≤ 10 mm > 10 mm 0.30 0.14-0.66 0.003
Lydiksen et al.182 2014 650 ≤ 10 mm > 10 mm 0.22 0.18-0.28 < 0.01

* Cox regression analysis was used for multivariate analyses of prognostic variables, 1 137 of the 391 included patients had
FIGO stages I or II, 2 14 of the 101 included patients had FIGO stages I or II, 3 15 of the 226 included patients had FIGO
stage II, 4 95 of the 242 included patients had FIGO stages I or II, 5 277 of the 3 126 included patients had FIGO stages IIB
or IIC, 6 8 of the 64 included patients had stage I-II disease at primary surgery, CI confidence interval, HR hazard ratio, NA

data not available, OR odd ratio.

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