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Table 4. Pooled data on the test accuracy of various techniques for SLN assessment

Authorreference Year Blue dye 99mTc Blue dye/99mTc Fluorescent materials with
near infrared imaging
Detection rate (patient basis)
Hassanzade et al.89 2013 78% (95% CI = 66-86) 94% (95% CI = 89-96) 95% (95% CI = 92-97) 85% (95% CI = 68-94)
Meads et al.90 2014 68.7% (95% CI = 63.1-74.0) NA
94.0% (95% CI = 90.5-96.4) 97.7% (95% CI = 96.6-98.5)
Detection rate (groin basis)
Hassanzade et al.89 2013 72% (95% CI = 62-80) 88% (95% CI = 81-92) 91% (95% CI = 87-94) 85% (95% CI = 64-95)

Sensitivity (patient basis) 2013 89% (95% CI = 65-99) 91% (95% CI = 81-96) 95% (95% CI = 92-98) NA
Hassanzade et al.89 2014 94% (95% CI = 69-99) 93% (95% CI = 89-96) 95% (95% CI = 89-97) NA
Lawrie et al.91
2013 86% (95% CI = 65-97) 95% (95% CI = 87-99) 95% (95% CI = 91-97) NA
Sensitivity (groin basis) 2014 92% (95% CI = 82-97) 91% (95% CI = 87-94) 94% (95% CI = 88-97) NA
Hassanzade et al.89
Lawrie et al.91

NA: not available

Table 5. Pooled data pulished by Hassanzade et al.89 on the test accuracy of SLN biopsy according to location of the
tumour and inclusion of patients with palpable or suspicious inguinal nodes in the study population)

Test accuracy Location of the tumour Inclusion of patients with palpable or suspicious
inguinal nodes
Lateral tumours Midline tumours
Yes No

Detection rate (patient basis) 93% (95% CI = 88-96) 95% (95% CI = 92-97) 92% (95% CI = 86-96 95% (95% CI = 92-97)
Detection rate (groin basis) 93% (95% CI = 88-96) 73% (95% CI = 67-78) 77% (95% CI = 63-88) 82% (95% CI = 76-87)
Sensitivity (patient basis) 92% (95% CI = 79-98) 90% (95% CI = 87-93) 90% (95% CI = 82-96) 92% (95% CI = 88-95)
Sensitivity (groin basis) 91% (95% CI = 75-98) 94% (95% CI = 91-97) 90% (95% CI = 78-97) 92% (95% CI = 89-95)

Table 6. Original studies presenting clinical parameters in patients
treated by SLNB versus ILND

Authorreference Year N SLN biopsy ILND p-value

Operation time 2015 128 76.2 min1 103.3 min1 < 0.001
Brammen et al.171 2008 75 85.5 min 120.7 min 0.002

Hefler et al.178

Hospital stay 2015 128 13.3 days 18.1 days 0.006
Brammen et al.171 22.9 days < 0.001
13.7 days2 < 0.0001
Hefler et al.178 2008 75 12.6 days

van der Zee et al.145 2008 403 8.4 days2

Inguinal drainage 2015 128 4.1 days 6.9 days < 0.001
Brammen et al.171 2008 75 3.3 days 6.9 days < 0.001

Hefler et al.178

1 mean value, 2 median value

 VULVAR CANCER - GUIDELINES 
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