Page 34 - ESGO - Vulvar cancer - Complete report_fxd2

Table 7. Original studies presenting data in patients treated with primary groin radiation

Authorreference Year N Radiotherapy regimen Groin recurrence Survival
Stehman et al.205 1992 52 Radiation: 18.5% (5/27)
Dose: 50 Gy at 3 cm Surgery: 0% (0/25) Median follow-up: > 36 months
Type: 50% electrons OS: 60% versus 86%
Radiation: 4.6% (6/65) DSS: 67% versus 92%
Manavi et al.206 1997 135 Dose: 45 Gy at 5 cm No radiation: 10% (7/70) DFS: 68% versus 92%
Katz et al.186 Type: telecobalt 0% (0/14) Follow-up: NA
Perez et al.207 5y-OS: 62.4% versus 93.7%
2003 14 Dose: 45 Gy 10.5% (2/19) Median follow-up: 98 months
Type: electrons and photons combined
Median follow-up: 60 months
1998 19 Dose: 50-70 Gy at 4 cm
Type: photons (electron boost)

5y-OS: 5-year overall survival, DFS: disease-free survival, DSS: disease-specific survival, Gy: Gray, NA: not available, OS: overall survival.

Table 8. Original studies presenting data in patients treated with neoadjuvant radiation

Authorreference Year N Radiotherapy regimen Recurrence Survival/complications
Boronow et al.208
1987 37 External beam and intracavitary: N = 22 Local: N = 5 Median follow-up: 38.4 months
Balat et al.209 Intracavitary only: N = 12 Pelvic: N = 1 Status: 59.5% (22/37) alive NED
External beam only: N = 3 Severe complications: 23%
Local: N = 5
2000 24 External beam: N = 24 Distant: N = 1 Median follow-up: NA
Status: 70.8% (17/24) alive NED
Rotmensch et al.210 1990 16 External beam: N = 16 Central: N = 4 Severe complications: NA
Distant: N = 2
Hacker et al.211 1984 8 External beam and intracavitary: N = 1 Median follow-up: 25 months
Jafari et al.212 External beam only: N = 7 NA Status: 56,3% (9/16) alive NED
Severe complications: 4%
1981 4 External beam: N = 4 Local: N = 0
Distant: N = 0 Median follow-up: NA
Fairey et al.213 1985 7 External beam: N = 7 Status: 62.5% (5/8) alive NED
Local: N = 1 Severe complications: 12%
Carlino et al.214 1984 6 Intracavitary: N = 6 Distant: N = 1
Median follow-up: NA
Pao et al.215 1988 2 NA Local: N = 2 Status: 100% (4/4) alive NED
Severe complications: 0%
NA
Median follow-up: NA
Status: 85.7% (6/7) alive NED
Severe complications: 14%

Median follow-up: NA
Status: NA
Severe complications: NA

Median follow-up: NA
Status: 100% (2/2) alive NED
Severe complications: 0%

NA: not available, NED: no evidence of disease and no recurrence.

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